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Abstract #4285

ODF-Fingerprinting Improves Reconstruction of Fibers Crossing at Shallow Angles: A Study on Diffusion Phantom

Patryk Filipiak1, Lee Basler2, Anthony Zuccolotto2, Ying-Chia Lin1, Dimitris G. Placantonakis3, Timothy Shepherd1, Walter Schneider4, Fernando E. Boada1, and Steven H. Baete1
1Center for Advanced Imaging Innovation and Research (CAI2R), NYU School of Medicine, New York, NY, United States, 2Psychology Software Tools, Inc., Pittsburgh, PA, United States, 3Department of Neurosurgery, Perlmutter Cancer Center, Neuroscience Institute, Kimmel Center for Stem Cell Biology, NYU School of Medicine, New York, NY, United States, 4University of Pittsburgh, Pittsburgh, PA, United States

ODF peak finding typically fails to reconstruct fibers crossing at angles below 45 degrees. We aim to break this barrier with ODF-Fingerprinting. Our approach replaces the peak finding mechanism with pattern matching, allowing to use all the information stored in ODFs. In this work, we study the ability of ODF-Fingerprinting to reconstruct fibers crossing at 90, 45, and 30 degrees in a diffusion phantom composed of textile tubes with 0.8µm diameter, approaching the anatomical scale of axons. Our approach reaches much higher sensitivity (84-100%) than the ODF peak finding (0-33%), especially at the shallow angles.

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