Abstract #4285

ODF-Fingerprinting Improves Reconstruction of Fibers Crossing at Shallow Angles: A Study on Diffusion Phantom

Patryk Filipiak¹, Lee Basler², Anthony Zuccolotto², Ying-Chia Lin¹, Dimitris G. Placantonakis³, Timothy Shepherd¹, Walter Schneider⁴, Fernando E. Boada¹, and Steven H. Baete¹

¹Center for Advanced Imaging Innovation and Research (CAI2R), NYU School of Medicine, New York, NY, United States, ²Psychology Software Tools, Inc., Pittsburgh, PA, United States, ³Department of Neurosurgery, Perlmutter Cancer Center, Neuroscience Institute, Kimmel Center for Stem Cell Biology, NYU School of Medicine, New York, NY, United States, ⁴University of Pittsburgh, Pittsburgh, PA, United States

ODF peak finding typically fails to reconstruct fibers crossing at angles below 45 degrees. We aim to break this barrier with ODF-Fingerprinting. Our approach replaces the peak finding mechanism with pattern matching, allowing to use all the information stored in ODFs. In this work, we study the ability of ODF-Fingerprinting to reconstruct fibers crossing at 90, 45, and 30 degrees in a diffusion phantom composed of textile tubes with 0.8µm diameter, approaching the anatomical scale of axons. Our approach reaches much higher sensitivity (84-100%) than the ODF peak finding (0-33%), especially at the shallow angles.

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