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Abstract #4316

Patient specific tracts-based analysis of diffusion compartment models: application to multiple sclerosis patients with acute optic neuritis

Olivier Commowick1, Renaud Hédouin1, Charlotte Laurent2, and Jean-Christophe Ferré1,3
1Univ Rennes, Inria, CNRS, Inserm, IRISA UMR 6074, Empenn - ERL U1228, Rennes, France, 2Ophthalmology department, CHU Rennes, Rennes, France, 3Radiology department, CHU Rennes, Rennes, France

Multiple sclerosis is a complex disease where voxel-based, group-based statistics of the brain microstructure have shown their limits in explaining patient evolution. This is first due to too simple diffusion models, mixing information. Voxel-based studies also lack knowledge on brain structural connectivity. Finally, group-based analysis does not describe well the specific patient status (a crucial point for clinicians). We propose an atlas-based framework, combined with advanced diffusion compartment models, for patient specific analysis of microstructural disease burden on major fiber bundles. We apply our framework to the analysis of optic radiations of MS patients with acute optic neuritis.

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