Abstract #4318

Microstructural Properties of Major White Matter Tracts in Constant Exotropia before and after Strabismus Surgery

Yanming Wang¹, Xiaoxiao Wang¹, Hongmei Shi^2,3, Lin Xia², Jiong Dong², Benedictor Alexander Nguchu¹, Jean De Dieu Uwisengeyimana¹, Yanpeng Liu¹, Du Zhang¹, Lixia Feng², and Bensheng Qiu¹

¹Hefei National Lab for Physical Sciences at the Microscale and the Centers for Biomedical Engineering, University of Science and Technology of China, Hefei, China, ²Department of Ophthalmology, The First Affiliated Hospital of Anhui Medical University, Hefei, China, ³Department of Ophthalmology, The People's Hospital of Bozhou, Bozhou, China

This study apply AFQ, in conjunction with MRtrix3 and ConTrack, to identify 24 major white matter fiber bundles in HCs, patients with XT before and after strabismus surgery. Meanwhile, we evaluate ocular dominance (OD) and stereo acuity of post-operative patients. We found that microstructures (MD) of vision-related fibers changed after surgery. Moreover, these changes were associated with indicators of OD. We infer that microstructural changes of the visual spatially related fiber bundles might contribute to the restoration of stereopsis, and the balanced binocular input may be more conducive to the improvements and restoration of binocular visual function.

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