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Abstract #4318

Microstructural Properties of Major White Matter Tracts in Constant Exotropia before and after Strabismus Surgery

Yanming Wang1, Xiaoxiao Wang1, Hongmei Shi2,3, Lin Xia2, Jiong Dong2, Benedictor Alexander Nguchu1, Jean De Dieu Uwisengeyimana1, Yanpeng Liu1, Du Zhang1, Lixia Feng2, and Bensheng Qiu1
1Hefei National Lab for Physical Sciences at the Microscale and the Centers for Biomedical Engineering, University of Science and Technology of China, Hefei, China, 2Department of Ophthalmology, The First Affiliated Hospital of Anhui Medical University, Hefei, China, 3Department of Ophthalmology, The People's Hospital of Bozhou, Bozhou, China

This study apply AFQ, in conjunction with MRtrix3 and ConTrack, to identify 24 major white matter fiber bundles in HCs, patients with XT before and after strabismus surgery. Meanwhile, we evaluate ocular dominance (OD) and stereo acuity of post-operative patients. We found that microstructures (MD) of vision-related fibers changed after surgery. Moreover, these changes were associated with indicators of OD. We infer that microstructural changes of the visual spatially related fiber bundles might contribute to the restoration of stereopsis, and the balanced binocular input may be more conducive to the improvements and restoration of binocular visual function.

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