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Abstract #4320

Tractography analysis of dopamine transporter genetic mouse models in Parkinson's disease

Sang-Jin Im1 and Hyeon-Man Baek1
1Lee Gil Ya Cancer and Diabetes Institute, Incheon, Korea, Republic of

Parkinson's disease is characterized by degeneration of dopaminergic nigrostriatal neurons with dysfunctional cortico–striatal–thalamic loops mainly in the basal ganglia. However, Parkinson’s disease studies on the neural connections between brain structural regions have not reached a clear consensus on how Parkinson’s disease effects the mouse brain. In this study, probabilistic tractography analysis was performed on important mouse brain structures related to Parkinson's disease mechanism, and pathways between each domain were visualized.

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