Abstract #4322

Simultaneous Oxygenation and Metabolic Imaging Relates Oxygen and Neuronal Metabolism in Acute Stroke

Tianxiao Zhang¹, Rong Guo^2,3, Tianyao Wang⁴, Zengping Lin¹, Yudu Li^2,3, Yibo Zhao^2,3, Jun Liu⁴, Danhong Wu⁵, Zheng Jin⁶, Xin Yu⁷, Zhi-Pei Liang^2,3, and Yao Li¹

¹School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, ²Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ³Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁴Radiology Department, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China, ⁵Neurology Department, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China, ⁶Shanghai Minhang Hospital of Integrated Traditional Chinese and Western Medicine Hospital, Shanghai, China, ⁷Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States

Elevated oxygen extraction fraction and impaired neurometabolic metabolism are hallmarks of at-risk tissue in acute ischemic stroke. This study investigated the concurrent changes of oxygen and neuronal metabolisms. In an 8-min scan using SPICE, we simultaneously obtained 3D maps of neurometabolites (2.0 x 3.0 x 3.0 mm³ nominal spatial resolution) and T₂'/oxygen extraction fraction (1.0 x 1.0 x 1.9 mm³ nominal resolution). Our results showed the expected changes in oxygenation and neurometabolite markers individually, and also their coupling. This study may lay a foundation for prediction of tissue viability in acute stroke using noninvasive multimodal high-resolution metabolic imaging.

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