We investigated remote effects of brain infarction. We previously demonstrated higher iron content (higher R2* values) in deep nuclei as a consequence of their disconnection. Here, we aimed at predicting such long term remote degeneration from the acute stage. Through a disconnectivity approach, we mapped the fibers that were likely to be disconnected by projecting the acute stroke masks on tractograms from 180 healthy volunteers. We showed that disconnected areas based on this approach were likely to show significantly higher iron content at follow-up. This validates the prediction of deep nuclei disconnection from acute stage through a disconnectivity approach.
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