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Abstract #4329

Revisit on the cerebrovascular responses to end-tidal CO2 fluctuations during spontaneous breathing as a surrogate of regional cerebrovascular reactivity assessment under hypercapnic challenge

Suk-tak Chan1, Karleyton C. Evans2, Tian-yue Song1, Andre van der Kouwe1, Bruce R. Rosen1, Yong-ping Zheng3, and Kenneth K. Kwong1
1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, 2Biogen, Inc., Cambridge, MA, United States, 3Department of Biomedical Engineering, Hong Kong Polytechnic University, Kowloon, Hong Kong

Regional cerebraovascular reactivity (CVR) to endogenous carbon dioxide (CO2) during spontaneous breathing (i.e. end-tidal partial pressure of CO2 (PETCO2) measured at rest), was substantially different from that obtained under externally applied CO2 challenge. Individual maps of CVR to endogenous CO2 showed significant inter-subject variability while CVR maps under hypercapnic challenge did not. Such inter-subject variability was not reduced by correction of respiratory effects. In addition, the CVR to end-tidal partial pressure of oxygen (PETO2) during spontaneous breathing shows less inter-subject variability. Our findings question the compatibility of using CVR during spontaneous breathing as a surrogate of CVR under hypercapnic challenge.

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