Abstract #4346

Is Arterial Spin Labeling Effective in Measuring Cerebrovascular Reactivity? A Test-retest Study on Impact of Labeling Efficiency

Taghi Rostami¹, Moss Y Zhao², Audry P Fan³, David Yen-Ting Chen⁴, Magdalina J Sokolska⁵, Jia Guo⁶, Yosuke Ishii⁷, David D Shin⁸, Mohamad Mehdi Khalighi², Dawn Holley², Kim Halbert², Andrea Otte², Brittney Williams², Jun-Hyung Park², Bin Shen², and Greg Zaharchuk²

¹Bioengineering, Stanford University, Stanford, CA, United States, ²Radiology, Stanford University, Stanford, CA, United States, ³Medical Imaging, UC Davis, Davis, CA, United States, ⁴Taipei Medical University, Taipei, Taiwan, ⁵University College London Hospitals, London, United Kingdom, ⁶University of California Riverside, Riverside, CA, United States, ⁷Tokyo Medical. and Dental University, Tokyo, Japan, ⁸GE Healthcare, Menlo Park, CA, United States

In this study, we examined repeatability of labeling efficiency of single- and multi-PLD arterial spin labeling (ASL) MRI before and after vasodilation in 15 normal subjects. Individual measurements of hematocrit and flow velocity in the carotid and vertebral arteries, obtained by phase-contrast (PC) MRI, were used to assess the labeling efficiency for both ASL methods. Our results showed that both labeling techniques achieved high repeatability before and after vasodilation (within-subject Coefficient of Variance pre-ACZ: 0.82 and 1.23%, and post-ACZ: 0.51 % and 1.00%).

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