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Abstract #4345

Changes in Functional Connectivity and Cognition in HIV Infected Individuals with  Cerebral Small Vessel Disease

Kyle Douglass Murray1, Alan Finkelstein1, Miriam Weber1, Jianhui Zhong1, and Giovanni Schifitto1
1University of Rochester, Rochester, NY, United States

HIV-infected individuals are at increased risk of developing cerebrovascular diseases, such as cerebral small vessel disease (CSVD). Further, cognitive deficits as a result of chronic infection are common. In this abstract, we use a graph theoretical analysis of resting-state functional connectivity to show that functional and cognitive changes are driven by both HIV-infection and CSVD. We observed correlations between global and local graph theory metrics and cognitive scores derived from neuropsychological testing in the presence of HIV. We also describe potential compensatory changes in global brain function to combat functional deficits from HIV and CSVD.

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