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Abstract #4344

Central pulse pressure and its influence on carotid artery morphology predict white matter hyperintensity volumes

Andrew Crofts1, Jessica J Steventon2, Joseph R Whittaker3, Marcello Venzi1, Hannah L Chandler4, Mahfoudha Al Shezawi5, Eric J Stohr6, Chris Pugh6, Barry McDonnell6, and Kevin Murphy1
1Cardiff University Brain Research Imaging Centre (CUBRIC), School of Physics and Astronomy, Cardiff University, Cardiff, United Kingdom, 2CUBRIC, School of Medicine, Cardiff University, Cardiff, United Kingdom, 3Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 4CUBRIC, School of Psychology, Cardiff University, Cardiff, United Kingdom, 5Cardiff Metropolitan University, Cardiff, United Arab Emirates, 6Cardiff Metropolitan University, Cardiff, United Kingdom

Cardiovascular risk factors have been linked with deteriorations in cerebrovascular function in the brain, causing cell loss, particularly in the white matter. The mechanisms by which cardiovascular risk factors influence the microvasculature is unclear. Increased blood pressure and associated arterial stiffness/morphological changes in larger cerebral vessels are thought to play a key role. Here, we demonstrate that central pulse pressure along with associated changes in carotid radius and tortuosity better predict the white matter lesion burden in the brain compared with other measures of blood pressure and systemic arterial stiffness.

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