This is a retrospective validation study of intravoxel incoherent motion (IVIM) over a range of physiologic conditions: normocapnia, hypercapnia, and post middle cerebral artery occlusion. We performed controlled two-day experiments in a canine model (n=17) of ischemic stroke with baseline (normocapnia) and hypercapnia on the first day followed by occlusion on the second. We compared IVIM perfusion and diffusion images with neutron capture microsphere perfusion, DSC perfusion, and Apparent Diffusion Coefficient (ADC) from standard DWI. We found excellent agreement between IVIM for both perfusion and diffusion indicating IVIM may serve as a means of stratifying acute stroke patients for treatment.
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