Abstract #4352

Mapping of Relative Water Exchange Index (rWEI) in Post Thrombectomy Patients

Young Ro Kim¹ and Jerrold L Boxerman²

¹Radiology, MGH, Charlestown, MA, United States, ²Neuroradiology, Brown University, Providence, RI, United States

Previously, water exchange index (WEI) was proposed to quantify the rate of water movement across the blood-brain barrier (BBB). Although efficient and clinically applicable, the technique could not reliably provide voxelwise WEI maps due to the inadequate signal to noise ratio (SNR). In remedy of this shortcoming, we here present the relative WEI (rWEI) method, which enables voxelwise mapping of BBB water exchange while significantly reducing the acquisition time (< 10 min). To confirm the validity of the technique, the rWEI maps were acquired in post thrombectomy patients with unilateral infarct and compared with the WEI values.

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