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Abstract #4353

Effect of low dose daily aspirin on cerebral blood flow and kidney function in hypertensive rats

Greg O Cron1, Rafael Glikstein2, Jean Francois Thibodeau3, Anthony Carter3, Chet E Holterman3, Alexey Gutsol3, Lihua Zhu3, Baptiste Lacoste3, and Chris Kennedy3
1Ottawa Hospital Research Institute, Ottawa, ON, Canada, 2The Ottawa Hospital, Ottawa, ON, Canada, 3University of Ottawa, Ottawa, ON, Canada

For hypertensive patients taking low-dose aspirin, there may be risk of kidney injury. NSAIDs block vasoactive prostaglandin production, potentially blunting the reopening of hypertension-constricted renal vessels, thereby decreasing renal blood flow. We hypothesized that hypertension would predispose rats to low-dose aspirin induced kidney and cerebrovascular injury. Hypertensive rats who received low-dose daily aspirin appeared to have decreased cerebral blood flow, however the data must be interpreted with caution, as statistical power was lacking. Of interest, rats given both AngII and ASA developed significant kidney and cerebrovascular injury, suggesting a possible deleterious effect of this drug combination on the vasculature.

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