For hypertensive patients taking low-dose aspirin, there may be risk of kidney injury. NSAIDs block vasoactive prostaglandin production, potentially blunting the reopening of hypertension-constricted renal vessels, thereby decreasing renal blood flow. We hypothesized that hypertension would predispose rats to low-dose aspirin induced kidney and cerebrovascular injury. Hypertensive rats who received low-dose daily aspirin appeared to have decreased cerebral blood flow, however the data must be interpreted with caution, as statistical power was lacking. Of interest, rats given both AngII and ASA developed significant kidney and cerebrovascular injury, suggesting a possible deleterious effect of this drug combination on the vasculature.
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