Abstract #4356

Quantitative Analysis of DCE-MRI Following Transient Middle Cerebral Artery Occlusion in a Novel Ovine Model

Alexandra Ereni King¹, Paul D Teal², Yu-Chieh Tzeng³, Annabel Jain Sorby-Adams⁴, Isabella Megan Bilecki⁴, Renée Jade Turner⁴, and Sergei Obruchkov⁵

¹School of Chemical and Physical Sciences, Victoria University of Wellington, Wellington, New Zealand, ²School of Engineering and Computer Science, Victoria University of Wellington, Wellington, New Zealand, ³Centre for Translational Physiology, University of Otago, Wellington, New Zealand, ⁴Discipline of Anatomy and Pathology, University of Adelaide, Adelaide, Australia, ⁵Robinson Research Institute, Victoria University of Wellington, Wellington, New Zealand

Following a surgical model of transient and ischaemic stroke, 20 sheep (24-36 months; 65-75kg; 10M, 10F) underwent 2h middle cerebral artery occlusion (MCAO). Dynamic Contrast Enhanced (DCE) MRI datasets were obtained capturing the healthy animal, and progression of the infarct at 24h, 3d, 6d and 28 d post-stroke. Based on established pharmacokinetic models, analysis of these DCE-MRI images allows for calculation of perfusion parameters. The surgical procedure used is standardised and reproducible, meaning that this dataset provides an opportunity for quantitative in vivo analysis of stroke evolution in a clinically-relevant, gyrencephalic large animal model.

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