Previous studies have demonstrated that pharmacological hypothermia could protect the brain from ischemia or traumatic brain injury in rodent models. However, it remains unknown how the brain is affected by the hypothermia in patients as the physiology and brain metabolism of human are very different from rodents. Large animal models have been recommended to improve clinical translation in the study of ischemia . In the present study, the effects of drug-induced hypothermia on the brain of adult macaque monkeys were examined using diffusion MRI. The results suggested large animals play an important role in neuroprotection research of stroke.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords