Abstract #0008

Wall shear stress and velocity pulsatility in the parent artery of an unruptured intracranial aneurysm - a 7T 4D flow MRI study.

Rick J. van Tuijl¹, Ynte M. Ruigrok², Kimberley M. Timmins¹, Birgitta K Velthuis¹, Pim van Ooij¹, Jaco J.M. Zwanenburg¹, and Irene C. van der Schaaf¹

¹Radiology, UMC Utrecht, Utrecht, Netherlands, ²Neurology, UMC Utrecht, Utrecht, Netherlands

Synopsis

The influence of maximum wall shear stress (WSS_MAX) and velocity pulsatility (vPI) are extensively investigated in aortic aneurysms, but its influence along the Circle of Willis (CoW) in patients with unruptured intracranial aneurysms (UIA) is unknown. Thirteen patients with an UIA were scanned at 7T-MRI using 4D phase-contrast MRI, comparing hemodynamic parameters between the parent artery of the UIA and the corresponding contralateral artery. The parent vessel of the UIA showed significantly higher WSS_MAX, blood-flow and velocity, and lower vPI compared to the unaffected contralateral side. This study supports a hemodynamic role in the aetiology of aneurysm formation.

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