Abstract #0007

Defining Normative Cerebral Hemodynamics in Cognitively Healthy Older Adults with 4D Flow MRI

Grant S Roberts¹, Anthony Peret², Leonardo Rivera-Rivera^1,3, Karly A Cody³, Howard A Rowley², Oliver Wieben^1,2, Sterling C Johnson³, Kevin M Johnson^1,2, and Laura B Eisenmenger²

¹Dept of Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, ²Dept of Radiology, University of Wisconsin - Madison, Madison, WI, United States, ³Dept of Medicine, University of Wisconsin - Madison, Madison, WI, United States

Synopsis

It has been shown that vascular disease is strongly associated with Alzheimer’s disease (AD). It is thus important to establish normative cerebrovascular hemodynamics in aging populations. In this study, we comprehensively assess macrovascular hemodynamics using 4D flow MRI to obtain flow rates and pulsatility indices in 110 cognitively healthy, older adults and correlate these measures with age, sex, atherosclerotic cardiovascular disease (ASCVD) risk scores, and APOE genotypes. We found a (1) negative correlation between flow vs. age and flow vs. ASCVD, (2) a positive correlation between pulsatility vs. age and pulsatility vs. ASCVD, and (3) no correlations with APOE genotypes.

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