Abstract #0006

Pseudo-Enhancement in Intracranial Aneurysms on Black-Blood MRI: Effects of Flow Rate, Spatial Resolution, and Additional Flow Suppression.

Mariya S. Pravdivtseva¹, Franziska Gaidzik², Philipp Berg², Carson Hoffman³, Leonardo A. Rivera-Rivera³, Rafael Medero⁴, Lindsay Bodart³, Alejandro Roldan-Alzate⁴, Michael A. Speidel³, Kevin M. Johnson³, Oliver Wieben³, Olav Jansen⁵, Jan-Bernd Hövener¹, and Naomi Larsen⁵

¹Section Biomedical Imaging, Molecular Imaging North Competence Center (MOIN CC), Department of Radiology and Neuroradiology, University Medical Center Schleswig-Holstein (UKSH), Kiel University, Kiel, Germany, ²Laboratory of Fluid Dynamics and Technical Flows, Forschungs campus STIMULATE, University of Magdeburg, Magdeburg, Germany, ³Department of Medical Physics and Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States, ⁴Department of Mechanical Engineering and Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States, ⁵Department of Radiology and Neuroradiology, University Medical Center Schleswig-Holstein, Kiel, Germany

Synopsis

An intracranial aneurysm is a life-threatening disease. Vessel-wall enhancement on black-blood MRI was associated with inflammation and proposed as a marker for higher aneurysm rupture risk. However, slow blood flow can mimic wall enhancement. Here, we studied the effects of flow rates, spatial resolution, and motion-sensitized driven equilibrium (MSDE) on black-blood MRI using printed aneurysm models. A hyperintense signal was observed in the models and co-localized with a slow flow. MSDE and higher flow rates reduced the hyperintensities. Slow-flow phenomena contribute substantially to aneurysm enhancement, vary with MRI parameters, and should be considered in rupture assessment.

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