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Abstract #0010

Sex-Differences in Intracranial Plaque Burden in Hypertensive Patients with Acute Ischemic Stroke: A Vessel Wall MR Imaging Study

Jae W. Song1, Jiayu Xiao2, Steven Y Cen2, Xiao Liu3, Fang Wu4, Konrad Schlick5, Qi Yang3, Shlee S Song5, and Zhaoyang Fan2
1University of Pennsylvania, Philadelphia, PA, United States, 2University of Southern California, Los Angeles, CA, United States, 3Chaoyang Hospital, Beijing, China, 4Xuanwu Hospital, Beijing, China, 5Cedars-Sinai Medical Center, Los Angeles, CA, United States


Hypertension is associated with intracranial atherosclerosis (ICAS) and is a leading cause of acute ischemic stroke (AIS). Given sex-differences in the severity of hypertension, we hypothesized sex-differences in ICAS burden among hypertensive patients with AIS. Results show males have significantly higher adjusted total plaque burdens than females. Subgroup analyses show treated hypertensive males with AIS have higher total proximal and bifurcation plaques than treated females. Untreated hypertensive females have significantly higher total proximal and bifurcation plaques compared to untreated males. The results suggest attention to differential hypertension management by sex may be warranted to reduce ICAS burden and AIS risk.

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