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Abstract #0011

Regional diffusion imaging changes related to obesity, after adjusting for other risk factors: the UK Biobank study

Karolina Wartolowska1 and Alastair JS Webb1
1University of Oxford, Oxford, United Kingdom


Small vessel disease is a common cause of white matter damage in older people. It is strongly associated with age, hypertension, diabetes, and obesity. We have investigated the associations between body mass index (BMI) and diffusion changes (adjusted for other risk factors) in data from UK Biobank. BMI was more strongly related to diffusion changes in inferior brain regions, depending on whether the white matter tracts were within the anterior or posterior circulation. Obesity affects white matter integrity, beyond the effect of cardiovascular risk factors.

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