Abstract #0012

Temporal correlation of functional connectivity with cerebral blood flow and T2 relaxation time in the monkey brain following ischemic stroke

Chun-Xia Li¹, Frank Tong², Doty Kempf¹, Leonard Howell¹, and Xiaodong Zhang¹

¹Emory University, Atlanta, GA, United States, ²Department of Radiology, Emory University, Atlanta, GA, United States

Synopsis

Somatosensory deficits are seen in most stroke patients and can improve during recovery from stroke as reported previously. However, the underlining mechanism of the recovery remains poorly understood. The nonhuman primate (NHP) model of stroke has demonstrated similar functional connectivity evolution as seen in stroke patients and the secondary somatosensory cortex (S2) in NHPs is recognized as a direct extrapolation of somatosensory cortex in human. In the present study, the progressive function alteration of S2 and its relationship with the cerebral blood flow (CBF) and T2 changes in the monkey brain during acute stroke were examined and evaluated.

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