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Abstract #0013

How vascular properties affect the BOLD contrast across cortical depth.

Wouter Schellekens1, Alex Bhogal1, Emiel Roefs1, Mario Báez-Yáñez1, Jeroen Siero1, and Natalia Petridou1
1UMC Utrecht, Utrecht, Netherlands


In the current study, we quantify vascular properties in relation to laminar BOLD fMRI signals for differently sized vascular compartments across cortical depth. Using hypercapnic and hyperoxic breathing conditions, while measuring from macro- and micro-vascular compartments, we estimate effects of dilation capacity, theoretical maximum signal intensity, and relative change in cerebral blood volume on laminar BOLD contrasts. We show that enlarged signals for larger pial veins are mainly caused by their capacity for dilation. BOLD signal differences between macro- and micro-vascular compartments are not likely caused by differences in theoretical maximum signal intensity, or relative changes in cerebral blood volume.

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