We report the final results of an NIH funded study of MRI-based quantification of liver iron. R2* MRI enables quantification of liver iron concentration (LIC), but the cross-vendor differences of R2*-based LIC estimation remain unknown. Therefore, we evaluated the performance of R2*-based LIC via a single-breath-hold, confounder-corrected R2*-MRI at both 1.5T and 3T, through a multi-center, multi-vendor study. We confirmed a linear relationship between R2* and LIC, with highly similar calibrations across centers and vendors. Calibrations for 1.5T and 3T were generated. The data generated in this study provide the necessary multi-center calibrations for broad dissemination of R2*-based LIC quantification.
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