Simultaneous gauging of liver fibrosis and inflammation using 3D single breath-hold Intenso MRE with the gravitational transducer.
Omar Isam Darwish1,2,3, Radhouene Neji1,3, Sami Jeljeli1, Nader S Metwalli4, Jenna Feeley4, Yaron Rotman4, Rebecca J Brown4, Marc Ghany4, David E Kleiner5, Daniel Staeb6, Peter Speier7, Ralph Sinkus1,2, and Ahmed M Gharib4
1King's College London, London, United Kingdom, 2INSERM U1148, LVTS, University Paris Diderot, Paris, France, 3MR Research Collaborations, Siemens Healthcare Limited, Frimley, United Kingdom, 4National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, United States, 5National Cancer Institute, Bethesda, MD, United States, 6MR Research Collaborations, Siemens Healthcare Limited, Melbourne, Australia, 7MR Application Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany
Successful deployment of 3D liver MRE in the clinical assessment of fibrosis and inflammation requires a single breath-hold sequence to avoid geometric misalignment between different breath-holds and a phase-stable and efficient vibration for adequate wave penetration. We show initial data of Intenso MRE estimating the shear wave speed (Cs [m/s]) and the loss modulus (G’’ [kPa]). Both Cs and G’’ reflect a dependency on Ishak fibrosis and inflammation scores, respectively, in patients with chronic liver disease. In addition, we compare the magnitude of the shear modulus (|G*|) measured with Intenso and to the commonly utilized SE-EPI in such patients.
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