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Abstract #0042

High-fidelity submillimeter-isotropic-resolution diffusion MRI through gSlider-BUDA and circular EPI with S-LORAKS reconstruction

Congyu Liao1,2, Uten Yarach3, Xiaozhi Cao1,2, Siddharth Srinivasan Iyer4, Nan Wang1,2, Tae Hyung Kim5,6, Berkin Bilgic5,6, Adam Kerr1,7, and Kawin Setsompop1,2
1Department of Radiology, Stanford University, Stanford, CA, United States, 2Department of Electrical Engineering, Stanford University, Stanford, CA, United States, 3Radiologic Technology Department, Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand, 4Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States, 5Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 6Department of Radiology, Harvard Medical School, Boston, MA, United States, 7Stanford Center for Cognitive and Neurobiological Imaging, Stanford University, Stanford, CA, United States


BUDA-cEPI combines a circular-EPI (cEPI) trajectory with Blip-Up and Down Acquisition (BUDA), to achieve high-fidelity diffusion imaging. It employs full-ramp-sampling to efficiently cover a circular k-space to shorten the readout-train and mitigate T2*-blurring. For further readout-shortening, a combined phase-encoding(PE) & readout(RO) partial-Fourier (pF) is employed, where PE-pF is resolved via opposing the blip-up and down EPI-shots, and S-LORAKS reconstruction is used to effectively fill-out the remaining k-space. This resulted in an acquisition with markedly-reduced TE and ~40% reduced echo-train-length and T2*-blurring compared to standard-EPI at the same Rinplane and PE-pF. To achieve high-SNR, BUDA-cEPI is also combined with a gSlider-multi-slab acquisition.

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