An interleaved 2H-MRSI / 13C-MRS protocol to obtain a complete picture of glucose turnover in the human liver at 7T is presented. A dedicated triple-tuned surface coil was used and the setup was optimized for temporal and spatial resolution, SNR (under the restraints of SAR) and robustness to assess hepatic glucose uptake and glycogen production. Data quality and initial kinetic data after oral deuterated glucose load is reported. Further optimization is intended to establish absolute concentrations and to generate kinetic models of metabolic fluxes.
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