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Abstract #0057

Interleaved 1H-MRI, 2H-MRSI and 13C-MRS for time-resolved in vivo elucidation of glucose metabolism in human liver at 7 T

Simone Poli1,2, Ahmed Fahiem Emara3, Edona Ballabani3, Angeline Buser3, Luc Tappy3, Lia Bally3, and Roland Kreis1,2
1Magnetic Resonance Methodology, Institute of Diagnostic and Interventional Neuroradiology, University of Bern, Bern, Switzerland, 2Translational Imaging Center, sitem-insel, Bern, Switzerland, 3Department of Diabetes, Endocrinology, Nutritional Medicine and Metabolism UDEM, Insel Hospital, University Hospital Bern, Bern, Switzerland

Synopsis

An interleaved 2H-MRSI / 13C-MRS protocol to obtain a complete picture of glucose turnover in the human liver at 7T is presented. A dedicated triple-tuned surface coil was used and the setup was optimized for temporal and spatial resolution, SNR (under the restraints of SAR) and robustness to assess hepatic glucose uptake and glycogen production. Data quality and initial kinetic data after oral deuterated glucose load is reported. Further optimization is intended to establish absolute concentrations and to generate kinetic models of metabolic fluxes.

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