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Abstract #0058

Quantification of cross-relaxation in human skeletal muscle using downfield 1H MRS at 7T

Sophia Swago1, Abigail Cember2, Puneet Bagga3, Neil Wilson2, Mark A. Elliott2, Ravi Prakash Reddy Nanga2, Ravinder Reddy2, and Walter Witschey2
1Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, 2Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, 3St. Jude Children's Research Hospital, Memphis, TN, United States


In the 1H magnetic resonance (MR) spectrum of human muscle, non-exchangeable proton resonances have been observed at 8.0, 8.2 and 8.5 ppm. While relaxation rate enhancement of these resonances was previously observed, their cross-relaxation rates with bulk water have not yet been determined. Knowledge of cross-relaxation rates could improve the design of MR techniques or serve as a potential biomarker. We quantify the cross-relaxation rate of these resonances with bulk water using selective and non-selective inversion-recovery downfield MRS at 7T. We observed the cross-relaxation rates of the 8.2 and 8.5 ppm resonances were significantly faster than the 8.0 ppm resonance.

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