Abstract #0059

The influence of cystathionine on neurochemical quantification in brain tumor in vivo magnetic resonance spectroscopy

Francesca Branzoli^1,2, Dinesh K Deelchand³, Roberto Liserre⁴, Pietro Luigi Poliani⁵, Lucia Nichelli⁶, Marc Sanson^2,7, Stéphane Lehéricy^1,2,6, and Małgorzata Marjańska³

¹Center for Neuroimaging Research - CENIR, Paris Brain Institute - ICM, Paris, France, ²UMR S 1127, Inserm U 1127, CNRS UMR 7225, Sorbonne University, Paris, France, ³Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, United States, ⁴Department of Radiology, Neuroradiology Unit, ASST Spedali Civili University Hospital, Brescia, Italy, ⁵Pathology Unit, Department of Molecular and Translational Medicine, Brescia University, Brescia, Italy, ⁶Department of Neuroradiology, Pitié Salpêtrière hospital, Paris, France, ⁷Department of Neurology 2, Pitié Salpêtrière hospital, Paris, France

Synopsis

We reported the ability of PRESS to detect cystathionine in vivo in patients with glioma and the effect of the omission of cystathionine on the quantification of the full neurochemical profile. We showed that the omission of cystathionine from analysis leads to severe biases on the quantification of other metabolites involved in cancer metabolism, e.g., aspartate, betaine, citrate, GABA and serine. Because cystathionine was shown to accumulate preferentially in gliomas with 1p/19q codeletion, omission of this metabolite may lead to the wrong evaluation of other metabolic changes in these tumors.

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