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Abstract #0065

Quantification of sulcal emergence in the fetal brain: hemispheric asymmetry and sex difference

Hyuk Jin Yun1, Hyun Ju Lee2, Joo Young Lee2, Tomo Tarui3, Caitlin K. Rollins1, Cynthia M. Ortinau4, Henry A. Feldman1, P. Ellen Grant1, and Kiho Im1
1Boston Children's Hospital, Boston, MA, United States, 2Hanyang University, Seoul, Korea, Republic of, 3Tufts Medical Center, Boston, MA, United States, 4Washington University in St. Louis, St. Louis, MO, United States


Sulcal emergence is important to assess normality of early fetal brain development. Thus, we proposed a quantitative approach to build an accurate timetable of sulcal emergence. Using a large sample of fetuses, we automatically extracted cortical surfaces and detected presence and absences of each sulcus. By fitting a logistic curve to sulcal presence/absence, the timing and inter-subject variability of sulcal emergence were estimated. We also found hemispheric asymmetry and sex difference in the timing and variability of sulcal emergence. Our quantitative timetable concurs with previous reports but provides more precise information and allow statistical comparison.

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