Abstract #0066
Temporal evolution of diffusion metrics in neonatal brains within the first few weeks postpartum
Pratheek Bobba1, Clara F Weber1,2, Adrian Mak1,3, Ajay Malhotra4, Kevin Sheth5, Sarah N Taylor6, Arastoo Vossough7,8, Patricia Ellen Grant9,10, Todd Constable1, Laura R Ment5,6, and Seyedmehdi Payabvash1
1Radiology, Yale School of Medicine, New Haven, CT, United States, 2Psychiatry and Psychotherapy, Social Neuroscience Lab, Department of Psychiatry and Psychotherapy, Lübeck University, Lübeck, Germany, Lübeck, Germany, 3CLAIM - Charité Lab for Artificial Intelligence in Medicine, Charité Universitätsmedizin Berlin, Berlin, Germany, Berlin, Germany, 4Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, United States, 5Neurology, Yale School of Medicine, New Haven, CT, United States, 6Pediatrics, Yale School of Medicine, New Haven, CT, United States, 7Radiology, Children's Hospital of Pennsylvania, Philadelphia, CT, United States, 8Radiology, University of Pennsylvania, Philadelphia, PA, United States, 9Division of Newborn Medicine, Boston Children's Hospital, Boston, MA, United States, 10Radiology, Boston Children's Hospital, Boston, MA, United States
Synopsis
In this retrospective cohort study, we characterized the age-related topography of quantitative diffusion metric evolution in 569 neonates scanned at our institution. We also studied the temporal rate of these metrics across different regions of the brain. and developed online interactive atlases depicting age-specific normative values of ADC and FA/MD in neonatal brains.
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