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Abstract #0067

Genetic and Environmental Contributions to Subcortical Gray Matter Microstructure and Volume in the Developing Brain

Richard Watts1, BJ Casey1, and Christopher Filippi2
1Department of Psychology, Yale University, New Haven, CT, United States, 2Tufts Medical Center, Boston, MA, United States


Using 9-10 year old monozygotic and dizygotic twins from the Adolescent Brain and Cognitive DevelopmentSM Study, we investigated the genetic and environmental contributions to microstructure (assessed using diffusion MRI and a restriction spectrum imaging model) and volume in nine subcortical gray matter regions. Heritability estimates range from 0.45 to 0.86 for microstructure, and 0.61 to 0.88 for volumes. Only the microstructure of the amygdala showed evidence of sensitivity to the shared environment.

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