Amyloid burden and vascular risk factors correlate with regional cerebral blood flow in a cognitively unimpaired population
Beatriz E. Padrela1, Luigi Lorenzini1, Lyduine E. Collij1, Mara ten Kate1, Anouk den Braber2,3, Jori Tomassen2, Bart N.M. van Beckel1, Pieter Jelle Visser2, Frederik Barkhof1,4, Jan Petr5, and Henk J.M.M. Mutsaerts1
1Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Center, Location VUmc, Amsterdam, Netherlands, 2Department of Neurology, Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, the Netherlands, Amsterdam, Netherlands, 3Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, Netherlands, 4Queen Square Institute of Neurology and Centre for Medical Image Computing (CMIC), University College London, London, United Kingdom, 5Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Dresden, Germany
Studying the association between cerebral blood flow (CBF), amyloid burden, and vascular risk factors in a cognitively unimpaired elderly population could clarify the role of CBF as a biomarker of cognitive decline. In 196 cognitively unimpaired participants, regional CBF was associated with regional amyloid-PET Centiloid. Vascular risk scores as measured by the Framingham risk score combined with amyloid Centiloid values were associated with increased CBF in vascular territories. Longitudinally, global CBF changes were associated with baseline precuneus amyloid burden.
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