Abstract #0077

Amyloid burden and vascular risk factors correlate with regional cerebral blood flow in a cognitively unimpaired population

Beatriz E. Padrela¹, Luigi Lorenzini¹, Lyduine E. Collij¹, Mara ten Kate¹, Anouk den Braber^2,3, Jori Tomassen², Bart N.M. van Beckel¹, Pieter Jelle Visser², Frederik Barkhof^1,4, Jan Petr⁵, and Henk J.M.M. Mutsaerts¹

¹Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Center, Location VUmc, Amsterdam, Netherlands, ²Department of Neurology, Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, the Netherlands, Amsterdam, Netherlands, ³Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, Netherlands, ⁴Queen Square Institute of Neurology and Centre for Medical Image Computing (CMIC), University College London, London, United Kingdom, ⁵Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Dresden, Germany

Synopsis

Studying the association between cerebral blood flow (CBF), amyloid burden, and vascular risk factors in a cognitively unimpaired elderly population could clarify the role of CBF as a biomarker of cognitive decline. In 196 cognitively unimpaired participants, regional CBF was associated with regional amyloid-PET Centiloid. Vascular risk scores as measured by the Framingham risk score combined with amyloid Centiloid values were associated with increased CBF in vascular territories. Longitudinally, global CBF changes were associated with baseline precuneus amyloid burden.

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