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Abstract #0088

In Vitro 4D Flow MRI for the Analysis of Aortic Coarctation

James Rice1,2, Labib Shahid1,2, Haben Berhane3,4, Cynthia K Rigsby5, Joshua D Robinson5, Lindsay M Griffin5, Michael Markl3,4, and Alejandro Roldan-Alzate1,2
1Mechanical Engineering, University of Wisconsin-Madison, Madison, WI, United States, 2Radiology, University of Wisconsin-Madison, Madison, WI, United States, 3Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States, 4Biomedical Engineering, Northwestern University, Evanston, IL, United States, 5Medical Imaging, Lurie Children's Hospital of Chicago, Chicago, IL, United States


4D flow MRI can be used to assess aortic coarctation (COA) repair hemodynamics in-vivo, however, challenges arise depending on hemodynamics and clinical presentation. This study presents a modeling pipeline for in-vitro COA hemodynamic assessment. Three patient-specific in-vitro models were created representing pre- and post-repair COA geometries, connected to a pulsatile flow loop, and imaged with 4D flow MRI to assess model hemodynamics. In all cases, aortic flow profiles are shown to improve after intervention. This agrees with clinical expectation, suggesting in-vitro 4D flow MRI can be used to analyze COA hemodynamics.

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