Abstract #0110

Free-Breathing Dual-Flip-Angle Multitasking Multi-Echo (MT-ME-dFA) MRI for Whole-Liver, B1+ Insensitive Quantification of T1, PDFF, and R2*

Nan Wang¹, Fardad M. Serry², Tianle Cao², Fei Han³, Yibin Xie², Xiaodong Zhong³, Sen Ma², Xiaoming Bi³, Mazen Noureddin², Shehnaz Hussain⁴, Vibhas Deshpande⁵, Anthony G. Christodoulou², and Debiao Li²

¹Stanford University, Stanford, CA, United States, ²Cedars-Sinai Medical Center, Los Angeles, CA, United States, ³Siemens Medical Solutions, Los Angeles, CA, United States, ⁴University of California, Davis, Davis, CA, United States, ⁵Siemens Medical Solutions, Austin, TX, United States

Synopsis

Quantitative T1, fat fraction, and R2* show promise for characterizing chronic liver diseases. We develop a dual-flip-angle MultiTasking Multi-Echo (MT-ME-dFA) technique to achieve B1+ insensitive, whole-liver joint T1/water-specific T1(T1w), fat fraction(PDFF), and R2* quantification. Respiratory motion is resolved through multidimensional low-rank tensor imaging, and B1+ robustness is achieved by modeling the inversion recovery with two alternating flip angles. Compared to the previously published single-flip-angle MT-ME approach, intra-subject variation on T1/T1w maps was substantially reduced; stronger correlation was achieved for T1/T1w, PDFF and R2* with references on phantom; root-mean-square of intra-subject T1/T1w variation was substantially reduced from 72ms/63ms to 39ms/31ms.

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