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Abstract #0110

Free-Breathing Dual-Flip-Angle Multitasking Multi-Echo (MT-ME-dFA) MRI for Whole-Liver, B1+ Insensitive Quantification of T1, PDFF, and R2*

Nan Wang1, Fardad M. Serry2, Tianle Cao2, Fei Han3, Yibin Xie2, Xiaodong Zhong3, Sen Ma2, Xiaoming Bi3, Mazen Noureddin2, Shehnaz Hussain4, Vibhas Deshpande5, Anthony G. Christodoulou2, and Debiao Li2
1Stanford University, Stanford, CA, United States, 2Cedars-Sinai Medical Center, Los Angeles, CA, United States, 3Siemens Medical Solutions, Los Angeles, CA, United States, 4University of California, Davis, Davis, CA, United States, 5Siemens Medical Solutions, Austin, TX, United States


Quantitative T1, fat fraction, and R2* show promise for characterizing chronic liver diseases. We develop a dual-flip-angle MultiTasking Multi-Echo (MT-ME-dFA) technique to achieve B1+ insensitive, whole-liver joint T1/water-specific T1(T1w), fat fraction(PDFF), and R2* quantification. Respiratory motion is resolved through multidimensional low-rank tensor imaging, and B1+ robustness is achieved by modeling the inversion recovery with two alternating flip angles. Compared to the previously published single-flip-angle MT-ME approach, intra-subject variation on T1/T1w maps was substantially reduced; stronger correlation was achieved for T1/T1w, PDFF and R2* with references on phantom; root-mean-square of intra-subject T1/T1w variation was substantially reduced from 72ms/63ms to 39ms/31ms.

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