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Abstract #0111

In Vivo High Frame Rate Cartilage Strain During Knee Varus Combining Spiral DENSE MRI and Compressed Sensing

Woowon Lee1, Emily Y Miller2, Hongtian Zhu1, and Corey P Neu1,2
1Paul M. Rady Department of Mechanical Engineering, University of Colorado, Boulder, CO, United States, 2Biomedical Engineering Program, University of Colorado, Boulder, CO, United States


Displacement encoding with stimulated echoes (DENSE) MRI is used to calculate pixel-level deformation maps of soft tissues under repetitive motion. It is a powerful technique that can quantify the mechanical behavior of tissues from displacement. We apply spiral DENSE MRI on human knees and obtain multi-frame displacement and strain maps during varus loading, leading to compressive motion on the medial condyle. Since high SNR DENSE images require long scanning time which is costly and less tolerable for participants, we additionally apply compressed sensing (CS) to reduce the imaging time to less than five minutes.

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