Abstract #0114

Pilot Tone-guided focused navigation for free-breathing whole-liver fat-water quantification

Adèle LC Mackowiak¹, Christopher W Roy¹, Mariana BL Falcaõ¹, Aurélien Bustin^1,2,3, Mario Bacher^1,4, Peter Speier⁴, Davide Piccini^1,5, Matthias Stuber^1,6, Naïk Vietti-Violi¹, and Jessica AM Bastiaansen^1,7,8

¹Department of Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, ²Department of Cardiovascular Imaging, Hôpital Cardiologique du Haut-Lévêque, CHU de Bordeaux, Bordeaux, France, ³IHU LIRYC, Electrophysiology and Heart Modeling Institute, INSERM U1045, Centre de Recherche Cardio-Thoracique de Bordeaux, Université de Bordeaux, Bordeaux, France, ⁴Siemens Healthcare GmbH, Erlangen, Germany, ⁵Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, ⁶CIBM Center for Biomedical Imaging, Lausanne, Switzerland, ⁷Department of Diagnostic, Interventional and Pediatric Radiology (DIPR), Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland, ⁸Translational Imaging Center, sitem-insel, Bern, Switzerland

Synopsis

A free-breathing 3D radial multi-echo GRE acquisition for whole-liver fat-water separation and quantification was proposed, which integrated retrospective respiratory motion extraction with Pilot Tone and motion-compensated reconstruction with focused navigation. The proposed framework was tested in 10 healthy volunteers at 1.5T. Post-processing of the 8 reconstructed and denoised echoes with a graphcut algorithm provided fat-water separated images and fat fraction maps of isotropic resolution. Images and maps were compared to breath-held reference 3D and 2D Cartesian acquisitions for validation of the quality of both motion compensation and fat-water separation.

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