Pilot Tone-guided focused navigation for free-breathing whole-liver fat-water quantification
Adèle LC Mackowiak1, Christopher W Roy1, Mariana BL Falcaõ1, Aurélien Bustin1,2,3, Mario Bacher1,4, Peter Speier4, Davide Piccini1,5, Matthias Stuber1,6, Naïk Vietti-Violi1, and Jessica AM Bastiaansen1,7,8
1Department of Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, 2Department of Cardiovascular Imaging, Hôpital Cardiologique du Haut-Lévêque, CHU de Bordeaux, Bordeaux, France, 3IHU LIRYC, Electrophysiology and Heart Modeling Institute, INSERM U1045, Centre de Recherche Cardio-Thoracique de Bordeaux, Université de Bordeaux, Bordeaux, France, 4Siemens Healthcare GmbH, Erlangen, Germany, 5Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, 6CIBM Center for Biomedical Imaging, Lausanne, Switzerland, 7Department of Diagnostic, Interventional and Pediatric Radiology (DIPR), Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland, 8Translational Imaging Center, sitem-insel, Bern, Switzerland
A free-breathing 3D radial multi-echo GRE acquisition for whole-liver fat-water separation and quantification was proposed, which integrated retrospective respiratory motion extraction with Pilot Tone and motion-compensated reconstruction with focused navigation. The proposed framework was tested in 10 healthy volunteers at 1.5T. Post-processing of the 8 reconstructed and denoised echoes with a graphcut algorithm provided fat-water separated images and fat fraction maps of isotropic resolution. Images and maps were compared to breath-held reference 3D and 2D Cartesian acquisitions for validation of the quality of both motion compensation and fat-water separation.
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