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Abstract #0130

Observation of 2H labeled compounds in the human brain with 1H versus 2H magnetic resonance spectroscopy at 9.4T

Loreen Ruhm1,2,3, Theresia Ziegs1,2, Andrew Wright1,2, Nikolai Avdievich1, and Anke Henning1,3
1Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, 2IMPRS for Cognitive and Systems Neuroscience, Eberhard-Karls University of Tuebingen, Tuebingen, Germany, 3Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States

Synopsis

The tracing of glucose metabolism is of interest in many pathologies of the human brain. In this abstract, we compare the information content of 2H MRSI detected deuterium metabolic imaging (DMI) to quantitative exchanged-labeled turnover 1H MRS (QELT), both measured at B0 = 9.4 Tesla. An uptake of 2H labeling was detectable for different metabolites for both methods. Consistent changes in 2H labeled Glx after the oral administration of [6,6’-2H2]-glucose were detected in the brain of healthy human subjects.

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