Abstract #0131
Longitudinal 23Na MRI in mild traumatic brain injury
Teresa Gerhalter1, Anna M Chen1, Seena Dehkharghani1,2, Rosemary Peralta1, James S. Babb1, Tamara Bushnik3, Alejandro Zarate3, Jonathan M Silver4, Brian S Im3, Stephen P Wall5, Ryan Brown1,6, Ivan I Kirov1,2,6, and Guillaume Madelin1
1Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, 2Department of Neurology, New York University Grossman School of Medicine, New York, NY, United States, 3Department of Rehabilitation Medicine, New York University Grossman School of Medicine, New York, NY, United States, 4Department of Psychiatry, New York University Grossman School of Medicine, New York, NY, United States, 5Ronald O. Perelman Department of Emergency Medicine, New York University Grossman School of Medicine, New York, NY, United States, 6Center for Advanced Imaging Innovation and Research, Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States
Synopsis
In this longitudinal sodium MRI study, mild traumatic brain injury (mTBI) patients and controls were scanned at 3T. Linear regression analysis was used to calculate total sodium concentrations (TSC) in global grey and white matter (GM, WM). Patient GM TSC increased back to control levels at 3-month and 1-year follow-ups. Decreased GM and WM TSC measured at one month were associated with worse cognitive performance, but not worse symptomalogy, at the follow-up visits.
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