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Abstract #0141

Cortical thickness at 3 years post-ischemic stroke: seeking vascular imaging signatures

Mohamed Salah Khlif1, Emilio Werden1, Laura Bird2, Natalia Brumley-Egorova1, and Amy Brodtmann1
1The Florey Institute of Neuroscience and Mental Health, Parkville, Australia, 2Turner Institute for Brain and Mental Health, Monash University, Clayton, Australia


Cortical thinning has been used both for diagnosis and disease monitoring. Few studies have examined longitudinal changes in cortical thickness following ischemic stroke. We compared cortical thinning, vortex-wise and region-wise, between ischemic stroke survivors and stroke-free control participants at 3 months and 3 years post-stroke using linear mixed-effect regression and correcting for age and sex. At 3 years, there was widespread cortical thinning in ischemic stroke, especially in the ipsilesional cortex, in lobes implicated in motor, sensory, and memory processing and recovery.

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