Cortical thinning has been used both for diagnosis and disease monitoring. Few studies have examined longitudinal changes in cortical thickness following ischemic stroke. We compared cortical thinning, vortex-wise and region-wise, between ischemic stroke survivors and stroke-free control participants at 3 months and 3 years post-stroke using linear mixed-effect regression and correcting for age and sex. At 3 years, there was widespread cortical thinning in ischemic stroke, especially in the ipsilesional cortex, in lobes implicated in motor, sensory, and memory processing and recovery.
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