Meeting Banner
Abstract #0143

Heterogeneous diffusivity changes within human stroke lesions measured with oscillating gradient spin echo diffusion MRI

Mi Zhou1, Robert Stobbe1, Brian Buck2, Ken Butcher2, Paige Fairall2, Annie Boyd1, Derek Emery3, Thorsten Feiweier4, and Christian Beaulieu1
1Biomedical Engineering, University of Alberta, Edmonton, AB, Canada, 2Neurology, University of Alberta, Edmonton, AB, Canada, 3Radiology and Diagnostic Imaging, University of Alberta, Edmonton, AB, Canada, 4Siemens Healthcare GmbH, Erlangen, Germany


Short diffusion time oscillating gradient spin echo (OGSE) showed less water diffusion reduction in acute human stroke lesions (n=28) than the typical clinically used long diffusion time pulsed gradient spin echo (PGSE) method. The diffusion time dependency is far greater in ischemic lesions, particularly white matter, than in contralateral healthy brain. These effects were heterogeneous across the lesion with larger OGSE-PGSE differences in regions indicative of larger axons. The range of MD decrease in lesions across patients as measured with OGSE and PGSE showed a linear correlation and is consistent with concomitant axon beading and swelling implied from prior simulations.

This abstract and the presentation materials are available to members only; a login is required.

Join Here