Short diffusion time oscillating gradient spin echo (OGSE) showed less water diffusion reduction in acute human stroke lesions (n=28) than the typical clinically used long diffusion time pulsed gradient spin echo (PGSE) method. The diffusion time dependency is far greater in ischemic lesions, particularly white matter, than in contralateral healthy brain. These effects were heterogeneous across the lesion with larger OGSE-PGSE differences in regions indicative of larger axons. The range of MD decrease in lesions across patients as measured with OGSE and PGSE showed a linear correlation and is consistent with concomitant axon beading and swelling implied from prior simulations.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords