Abstract #0144

Sensing brain plasticity after stroke using magnetic resonance elastography

Giacomo Annio^1,2, Gabrielle Mangin¹, Marco Barbero-Mota¹, Giuseppina Caligiuri¹, Antonino Nicoletti¹, Katharina Schregel³, and Ralph Sinkus^1,4

¹INSERM UMRS1148 - Laboratory for Vascular Translational Science, University Paris, Paris, France, ²School of Biomedical Engineering and Imaging Sciences, King’s College London, London, United Kingdom, ³Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany, ⁴School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom

Synopsis

Stroke is the leading cause of death globally. The infarcted area undergoes a deprivation of oxygen and energy, followed by multiple transient events and reorganization processes called ischemic cascade. MRI is the reference tool for accurate diagnosis, volumetric assessments and age determination of the lesion. The aim of the present study was to investigate the time course of changes in tissue biomechanics after an ischemic event in mice using MRE and study the relationship between stroke volume and tissue biomechanics, to explore a potential role of MRE in assessing the post stroke recovery.

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