A novel motion-and-time resolved 4D oxy-wavelet MRI (4D-fMRI acquired with oscillating hypoxia challenges, analyzed by a continuous wavelet transform mimicking experimental oscillations) can acquire fetal MRI with high spatiotemporal resolution and can probe mitochondrial functions in live fetal brains. 4D oxy-wavelet MRI outcomes were validated with Oroboros mitochondrial function assays and correlated with mitochondrial targeting drug JP4-039 in a fetal irradiation injury mouse model. The mouse fetuses showed poor 4D oxy-wavelet outcomes had poor mitochondrial functions and vice versa. Furthermore, an automated time-frequency analysis scheme can correctly differentiate normal vs irradiated fetuses, paving the way for future AI-based automatic diagnosis.
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