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Abstract #0153

Evaluation of the lipid composition in mice transplanted with obese human microbiota using magnetic resonance spectroscopy

Joao Piraquive1,2, Franck Desmoulin2,3, José Manuel Fernandez-Real4, Rémy Burcelin1, Xavier Collet1,2, and Anne Bouloumié1
1Institute of Metabolic and Cardiovascular Diseases (I2MC), Team Dynamix, Toulouse, France, 2Regional center of functional exploration and experimental resources (CREFRE), Noninvasive exploration service (ENI), Toulouse, France, 3Toulouse NeuroImaging Center (ToNIC), INSERM UMR 2314/UPS, Toulouse, France, 4Unitat de Diabetologia, Endocrinologia i Nutricio, University Hospital of Girona Dr. Josep Trueta, Girona, Spain


In this project, mice devoid of microbiota were transplanted with human microbiota from obese patients. Our work focused on evaluating and comparing the lipid composition in the white adipose in mice with different gut microbiota backgrounds using MRS. Our findings showed differences in white adipose tissue storage, lipid composition, and fatty acid composition among the different groups. This suggests that MRS can be used as a noninvasive tool to monitor dysbiotic gut microbiota in obese patients and evaluate a potential therapeutic response for obesity.

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