In this project, mice devoid of microbiota were transplanted with human microbiota from obese patients. Our work focused on evaluating and comparing the lipid composition in the white adipose in mice with different gut microbiota backgrounds using MRS. Our findings showed differences in white adipose tissue storage, lipid composition, and fatty acid composition among the different groups. This suggests that MRS can be used as a noninvasive tool to monitor dysbiotic gut microbiota in obese patients and evaluate a potential therapeutic response for obesity.
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