Meeting Banner
Abstract #0157

Mechanically Induced contrast in OA and control cartilage tissues  at histological length scales probed by multi-scale 1H/23Na MRS and MRI at 9.4T.

Galina Pavlovskaya1, Onur Belek2, Thomas Meersmann1, Christopher Philp1, Jane McLaren2, David A Walsh2, and Brigitte E Scammell2
1SPMIC/Medicine, University of Nottingham, Nottingham, United Kingdom, 2Medicine, University of Nottingham, Nottingham, United Kingdom


We reveal intriguing experimental results providing the evidence that triple quantum filtered sodium relaxation time associated with histologically confirmed sodium bound to glycosaminoglycans (GAGs) in the cartilage matrix could be a marker for earlier osteoarthritis. The change appears only when cartilage specimens are subjected to mechanical load corresponding to 200N force applied normal to the cartilage surface. Hence, this mechanically induced change can potentially serve as a health score of cartilage tissues in health and disease in vivo.

This abstract and the presentation materials are available to members only; a login is required.

Join Here