We reveal intriguing experimental results providing the evidence that triple quantum filtered sodium relaxation time associated with histologically confirmed sodium bound to glycosaminoglycans (GAGs) in the cartilage matrix could be a marker for earlier osteoarthritis. The change appears only when cartilage specimens are subjected to mechanical load corresponding to 200N force applied normal to the cartilage surface. Hence, this mechanically induced change can potentially serve as a health score of cartilage tissues in health and disease in vivo.
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