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Abstract #0158

Renal fibrosis investigated by in vivo multifrequency MR elastography in a rat model of chronic kidney disease.

Karolina Garczyńska1,2, Julia Hahndorf1, Nicola Stolzenburg1, Matthias Taupitz1, Jürgen Braun3, Ingolf Sack1, Jörg Schnorr1, and Jing Guo1
1Department of Radiology, Charité Universitätsmedizin Berlin, Berlin, Germany, 2Department of Veterinary Pathology, Free University of Berlin, Berlin, Germany, 3Institute of Medical Informatics, Charité Universitätsmedizin Berlin, Berlin, Germany


Using in vivo tomoelastography and multiparametric MRI (mp-MRI) we investigated kidneys of 10 rats with adenine-induced chronic kidney disease (CKD) and 8 healthy controls. In CKD rats, increased kidney volume, shear wave speed (SWS, related to stiffness) and wave penetration rate (related to inverse viscosity) were observed, while water diffusivity was reduced. These imaging findings were correlated with histopathologically quantified renal fibrosis. Our results suggested that collagen accumulation during CKD progression transforms soft-compliant renal tissue into a more rigid-solid state with reduced water mobility and shows that tomoelastography is a promising tool for non-invasive monitoring of disease progression.

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