R1ρ Dispersion Imaging of Normal Tissues in Human Subjects at 3T
Fatemeh Adelnia1,2, Zhongliang Zu1,2, Feng Wang1,2, Saikat Sengupta1,2, Kevin D Harkins1,2, and John C Gore1,2,3
1Vanderbilt University Institute of Imaging Science, Nashville, TN, United States, 2Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, 3Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States
R1ρ dispersion over a range of weak locking fields has the potential to reveal information on microvascular geometry and density based on diffusion effects. Using an efficient protocol for data acquisition and theoretical fits to a simple model we present estimates of novel parameters derived from R1ρ dispersion measurements that are in the range expected for microvasculature structure. Our in vivo results support the application of R1ρ dispersion at low locking fields in human studies. However, further validation such as ex vivo studies need to be performed.
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