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Abstract #0207

Simultaneous hemodynamic and structural imaging of ischemic stroke with MR Fingerprinting ASL

Hongli Fan1,2, Pan Su2, Doris Da May Lin3, Emily B. Goldberg3, Alexandra Walker3, Richard Leigh3, Argye E. Hillis3, and Hanzhang Lu1,2,4
1Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2The Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

Synopsis

Tissue perfusion and structural imaging provides important information in the evaluation of ischemic stroke. MR-fingerprinting (MRF) arterial spin labeling (ASL) is a novel noninvasive method of ASL perfusion that allows simultaneous estimation of cerebral blood flow (CBF), bolus arrival time (BAT), and tissue T1 map in a single scan of <4 minutes. Here we evaluated the utility of MRF-ASL in ischemic stroke patients in depicting hemodynamic and structural abnormalities, as well as predicting neurological deficits and disability.

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