Abstract #0207

Simultaneous hemodynamic and structural imaging of ischemic stroke with MR Fingerprinting ASL

Hongli Fan^1,2, Pan Su², Doris Da May Lin³, Emily B. Goldberg³, Alexandra Walker³, Richard Leigh³, Argye E. Hillis³, and Hanzhang Lu^1,2,4

¹Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²The Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

Synopsis

Tissue perfusion and structural imaging provides important information in the evaluation of ischemic stroke. MR-fingerprinting (MRF) arterial spin labeling (ASL) is a novel noninvasive method of ASL perfusion that allows simultaneous estimation of cerebral blood flow (CBF), bolus arrival time (BAT), and tissue T₁ map in a single scan of <4 minutes. Here we evaluated the utility of MRF-ASL in ischemic stroke patients in depicting hemodynamic and structural abnormalities, as well as predicting neurological deficits and disability.

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