A 3D multi-parameter MRF imaging technique capable of quantifying 4 different parameters (T1, T2, T1ρ, B1) was developed for multiple sclerosis(MS) application. The 3D-MRF technique was tested with multiple shots on a standardized NIST/ISMRM phantom, and brain imaging in 5 healthy volunteers. The 3D-MRF was also tested on two MS patients with chronic and enhancing MS lesions. The phantom studies demonstrate that quantitative maps are in agreement with reference, healthy volunteer studies show the agreement between multiple shots and SNR improvement with increasing shots. The MS patient results demonstrate the potential use of mutli-parameter quantitative mapping for WM characterization.
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