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Abstract #0206

Three dimensional multi-parameter brain mapping using MR fingerprinting for characterization of multiple sclerosis lesions

Rajiv G Menon1, Azadeh Sharafi1, Marco Muccio1, Tyler E. Smith2, Ilya Kister2, Yulin Ge1, and Ravinder R Regatte1
1Center for Biomedical Imaging, Grossman school of Medicine, NYU Langone Health, New York, NY, United States, 2Department of Neurology, Grossman School of Medicine, NYU Langone Health, New York, NY, United States


A 3D multi-parameter MRF imaging technique capable of quantifying 4 different parameters (T1, T2, T, B1) was developed for multiple sclerosis(MS) application. The 3D-MRF technique was tested with multiple shots on a standardized NIST/ISMRM phantom, and brain imaging in 5 healthy volunteers. The 3D-MRF was also tested on two MS patients with chronic and enhancing MS lesions. The phantom studies demonstrate that quantitative maps are in agreement with reference, healthy volunteer studies show the agreement between multiple shots and SNR improvement with increasing shots. The MS patient results demonstrate the potential use of mutli-parameter quantitative mapping for WM characterization.

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