Imaging Optic Nerve Pathology and Dysfunction in Multiple Sclerosis Using Diffusion Basis Spectrum imaging
Tsen-Hsuan (Abby) Lin1, William M Spees1, Michael Wallendorf2, Peng Sun1,3, Junqian Xu4, Anne H Cross5,6, and Sheng-Kwei Song1,6
1Radiology, Washington University School of Medicine, St. Louis, MO, United States, 2Biostatistics, Washington University School of Medicine, St. Louis, MO, United States, 3Imaging Physics, MD Anderson Cancer Center, Houston, TX, United States, 4Radiology, Baylor College of Medicine, Houston, TX, United States, 5Neurology, Washington Univeristy School of Medicine, St. Louis, MO, United States, 6Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, United States
We have introduced diffusion basis spectrum imaging (DBSI) to detect, differentiate, and quantify coexisting pathologies in people with multiple sclerosis (MS). Recently, we performed functional DBSI and DTI with flashing-checkerboard stimulation. DBSI-derived radial diffusivity (DBSI-RD) decreased significantly during visual stimulation while DTI-RD did not change. In this study, we employed fDBSI to assess optic nerve function and pathology simultaneously in MS. Axonal loss and vasogenic edema/increased extracellular space attenuated optic nerve response to visual stimulation.
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