Abstract #0204

Myelin water and multi-shell diffusion imaging provide unique information about multiple sclerosis myelin and axonal damage

Tigris S. Joseph^1,2, Hanwen Liu^2,3,4, Shannon H. Kolind^1,2,4,5, Guojun Zhao⁴, Peng Sun⁶, Robert Carruthers⁴, Alice Schabas⁴, Ana-Luiza Sayao⁴, Virginia Devonshire⁴, Roger Tam^5,7, G. R. Wayne Moore^2,4,8, David K. B. Li^4,5, Sheng-Kwei Song⁹, Anthony Traboulsee⁴, Irene M. Vavasour^2,5, and Cornelia Laule^1,2,5,8

¹Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, ²International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, BC, Canada, ³Montreal Neurological Institute - Hospital, McGill University, Montreal, QC, Canada, ⁴Medicine, University of British Columbia, Vancouver, BC, Canada, ⁵Radiology, University of British Columbia, Vancouver, BC, Canada, ⁶Imaging Physics, MD Anderson Cancer Center, Houston, TX, United States, ⁷School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada, ⁸Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada, ⁹Radiology, Washington University, St. Louis, MO, United States

Synopsis

Myelin Water Imaging (MWI), Diffusion Basis Spectrum Imaging (DBSI) and Neurite Orientation Dispersion and Density Imaging (NODDI) were used to assessed relationships between myelin and axon-related measures in 122 multiple sclerosis (MS) participants and 16 healthy controls. Neurite density index (NDI) correlated strongly with radial diffusivity and weakly with myelin water fraction, suggesting that radial diffusivity also captures diffusion in dendrites. The lack of correlation between NDI and fiber fraction was surprising given that both metrics are meant to relate to axon density. MWI, DBSI and NODDI provide unique and complementary information about MS damage.

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