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Abstract #0204

Myelin water and multi-shell diffusion imaging provide unique information about multiple sclerosis myelin and axonal damage

Tigris S. Joseph1,2, Hanwen Liu2,3,4, Shannon H. Kolind1,2,4,5, Guojun Zhao4, Peng Sun6, Robert Carruthers4, Alice Schabas4, Ana-Luiza Sayao4, Virginia Devonshire4, Roger Tam5,7, G. R. Wayne Moore2,4,8, David K. B. Li4,5, Sheng-Kwei Song9, Anthony Traboulsee4, Irene M. Vavasour2,5, and Cornelia Laule1,2,5,8
1Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, 2International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, BC, Canada, 3Montreal Neurological Institute - Hospital, McGill University, Montreal, QC, Canada, 4Medicine, University of British Columbia, Vancouver, BC, Canada, 5Radiology, University of British Columbia, Vancouver, BC, Canada, 6Imaging Physics, MD Anderson Cancer Center, Houston, TX, United States, 7School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada, 8Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada, 9Radiology, Washington University, St. Louis, MO, United States

Synopsis

Myelin Water Imaging (MWI), Diffusion Basis Spectrum Imaging (DBSI) and Neurite Orientation Dispersion and Density Imaging (NODDI) were used to assessed relationships between myelin and axon-related measures in 122 multiple sclerosis (MS) participants and 16 healthy controls. Neurite density index (NDI) correlated strongly with radial diffusivity and weakly with myelin water fraction, suggesting that radial diffusivity also captures diffusion in dendrites. The lack of correlation between NDI and fiber fraction was surprising given that both metrics are meant to relate to axon density. MWI, DBSI and NODDI provide unique and complementary information about MS damage.

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